EXPERIMENTAL AND THEORETICAL VIBRATIONAL SPECTROSCOPY STUDIES OF ACETOHYDROXAMIC ACID AND DESFERRIOXAMINE B IN AQUEOUS SOLUTION: EFFECTS OF PH AND IRON COMPLEXATION
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dc.contributor.author | Edwards D.C. | |
dc.contributor.author | Nielsen S.B. | |
dc.contributor.author | Jarzecki A.A. | |
dc.contributor.author | Spiro T.G. | |
dc.contributor.author | Myneni S.C.B. | |
dc.date.accessioned | 2023-11-18T10:28:18Z | |
dc.date.available | 2023-11-18T10:28:18Z | |
dc.date.issued | 2005 | |
dc.identifier | https://www.elibrary.ru/item.asp?id=12092186 | |
dc.identifier.citation | Geochimica et Cosmochimica Acta, 2005, 69, 13, 3237-3248 | |
dc.identifier.issn | 0016-7037 | |
dc.identifier.uri | https://repository.geologyscience.ru/handle/123456789/41875 | |
dc.description.abstract | The deprotonation and iron complexation of the hydroxamate siderophore, desferrioxamine B (desB), and a model hydroxamate ligand, acetohydroxamic acid (aHa), were studied using infrared, resonance Raman and UV-vis spectroscopy. The experimental spectra were interpreted by a comparison with DFT calculated spectra of aHa (partly hydrated) and desB (reactive groups of unhydrated molecule) at the B3LYP/6-31G* level of theory. The ab initio models include three water molecules surrounding the deprotonation site of aHa to account for partial hydration. Experiments and calculations were also conducted in D2O to verify spectral assignments. These studies of aHa suggest that the cis-keto-aHa is the dominant form, and its deprotonation occurs at the oxime oxygen atom in aqueous solutions. The stable form of iron-complexed aHa is identified as Fe(aHa)3 for a wide range of pH conditions. The spectral information of aHa and an ab initio model of desB were used to interpret the chemical state of different functional groups in desB. Vibrational spectra of desB indicate that the oxime and amide carbonyl groups can be identified unambiguously. Vibrational spectral analysis of the oxime carbonyl after deprotonation and iron complexation of desB indicates that the conformational changes between anion and the iron-complexed anion are small. Enhanced electron delocalization in the oxime group of Fe-desB when compared to that of Fe(aHa)3 may be responsible for higher stability constant of the former. | |
dc.title | EXPERIMENTAL AND THEORETICAL VIBRATIONAL SPECTROSCOPY STUDIES OF ACETOHYDROXAMIC ACID AND DESFERRIOXAMINE B IN AQUEOUS SOLUTION: EFFECTS OF PH AND IRON COMPLEXATION | |
dc.type | Статья | |
dc.identifier.doi | 10.1016/j.gca.2005.01.030 |
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